Conținutul Abstract Recently, adoption of novel drugs for systemic treatment of metastatic prostate cancer term aggressive has led to a striking improvement of response rate and survival in both hormone-sensitive and castration-resistant disease.
In most cancer term aggressive, prostate cancer essentially depends on androgen receptor signaling axis, even in castration-resistant setting, and hence may be targeted by second generation hormonal therapy.
However, a subset of patients bears androgen-independent cancer biology with a short-term response to hormonal treatment, cancer term aggressive and extensive visceral metastases, low PSA levels and poor outcomes.
Identification and specific management of these rapidly fatal malignancies is of an unmet papilloma jelentese term aggressive need since their classification and utilized therapeutic regimens vary significantly. Unfortunately, molecular pathways have not been sufficiently elucidated yet in order to provide an effective targeted treatment with a prolonged cancer term aggressive.
Lack of diagnostic and predictive biomarkers for these cancers makes successful counteractions against them even more sophisticated.
In this comprehensive review, we cancer term aggressive at summarizing the current body of literature reporting on causal molecular machinery as well as diagnostic and therapeutic concepts of aggressive prostate tumors and draw clinically relevant conclusions for the up-to-date sensible disease management.