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Basophils are also a significant indicator for the presence of certain malignancies such as anemia workup myeloproliferative neoplasms and acute myeloid leukemia. In the current manuscript we present a statistically significant correlation between persistent basophilia in primary myelofibrosis PMF and the risk for the subsequent development of acute myeloid leukemia.

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All the patients were diagnosed according to the WHO criteria. When comparing both groups of patients with myelofibrosis, the group with subsequent Anemia workup development and the one without AML, the follow-up did not present statistically significant differences between the two groups.

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Anemia workup the univariate analysis, patients who progressed to AML anemia workup more frequently basophilia, longer basophilia duration, higher pre-therapy absolute, and relative basophil count and presented more frequently calreticulin CALR mutations. In the current study, we emphasize the need for a closer clinical monitoring for chronic MPNs with marked basophilia, with an important potential clinical impact.

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